It is also used for fever, hysteria, and high blood pressure. 2.It is an effective tonic which usually is administered for insufficiency of blood due to impairment of the heart and spleen resulting from overstrain, manifested as palpitation, amnesia and insomnia. Some people use gentian to prevent muscle spasms, treat parasitic worms, start menstrual periods, and as a germ killer. Wien Med Wochenschr 1999;149:202-8. J Sep.Sci 2008;31(1):195-200. This information should not be used to decide whether or not to take this product. The species has been documented as far back as 180 BC and the roots were used medicinally in tonics. There isn't enough information to know if gentian is effective for the other conditions people use it for, including: stomach disorders, diarrhea, fever, heartburn, vomiting, menstrual disorders, cancer, and others. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. (detailed description of each of the ratings). Radix Gentianae Scabrae (known as Chinese or Japanese gentian) is indigenous to Korea, China, and Japan, and contains chemical constituents similar to these of G. lutea.WHO 1999, The gentians have been used for centuries as bitters to stimulate the appetite, improve digestion, and treat a variety of GI complaints (eg, diarrhea, heartburn, stomach ache, vomiting). Gentian root is not related to the gentian violet dye (methylrosaniline chloride). Stemless gentian also contains the xanthone glycoside gentiacauloside. Avoid use in pregnancy and lactation.WHO 1999. Gentian, a true bitter healing plant. Atherosclerosis 2007;194(2):317-325. View abstract. View abstract. The extracts are used in a variety of foods, cosmetics, and some antismoking products. Discover Your Allergy Triggers. View abstract. Citova, I., Ganzera, M., Stuppner, H., and Solich, P. Determination of gentisin, isogentisin, and amarogentin in Gentiana lutea L. by capillary electrophoresis. The highly toxic white hellebore (Veratrum album) can be mistaken for gentian and has caused accidental poisoning when used in homemade preparations. View abstract. There isn't enough information to know if gentian is safe when used in medicinal amounts other than as part of the combination product. Clinical and analytical data. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Gentiana lutea (Gentian) root extract. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182. This is only a brief summary of general information about this product. Case reports are lacking; however, hemostatic activity has been demonstrated in vitro for extracts of G. luteaBakuridze 2009 and isogentisin and several other compounds from gentian inhibited monoamine oxidase.Suzuki 1978, Haraguchi 2004 If substantiated in a clinical setting, these properties may have implications for coadministration of anticoagulant or antidepressant medicines. If you plan to make your own gentian preparation, be sure you identify gentian correctly. J Chromatogr 1983;281:263-271. A series of studies have found that it has antimicrobial and antifungal properties. View abstract. symphyandra on the central nervous system in mice. Pharm.Biol. Medically reviewed by Drugs.com. If you have issues with poor circulation, this herb may be helpful for you as well, as it can invigorate the blood and improve circulation to all parts of the body. turmeric, echinacea, saw palmetto, milk thistle, Ginkgo Biloba. View abstract. GENTIANA LUTEA ROOT EXTRACT is classified as : Skin conditioning; CAS Number: 72968-42-4 / 97676-22-7 EINECS/ELINCS No: 277-139-0 / - COSING REF No: 56165 Chem/IUPAC Name: Gentiana Lutea Root Extract is an extract of the rhizomes and roots of the Gentian, Gentiana lutea, Gentianaceae 7. Uncini Manganelli RE, Chericoni S, Baragatti B. Ethnopharmacobotany in Tuscany: plants used as antihypertensives. View abstract. Monoamine oxidase inhibitors from Gentiana lutea. View abstract. Extracts of G. lutea were active in carageenan-induced rat paw edema, xylol-induced mouse ear edema, and cotton-pellet granulatoma models. There is some scientific evidence that gentian, when combined with other herbs including European elder flower, verbena, cowslip flower, and sorrel, might help for treating symptoms of sinusitis. Szucs, Z., Danos, B., and Nyiredy, S. Comparative analysis of the underground parts of Gentiana species by HPLC with diode-array and mass spectrometric detection. This information relates to an herbal, vitamin, mineral or other dietary supplement. 2008;59(6):377-384. ⦠Numerous species of gentian native to China are used in Chinese traditional medicine. It is used as a liver tonic and for the making of Angostura bitters. Takino, K., Koshioka, M., and Kawaguchi, M. Quantitative determination of bitter components in gentianaceous plants. Salicylic Acid. View abstract. Wang, C. H., Cheng, X. M., Bligh, S. W., White, K. N., Branford-White, C. J., and Wang, Z. T. Pharmacokinetics and bioavailability of gentiopicroside from decoctions of Gentianae and Longdan Xiegan Tang after oral administration in rats--comparison with gentiopicroside alone. The xanthones gentiacaulein and gentiakochianin are responsible for the vasodilator action of the roots of Gentiana kochiana. Rojas, A., Bah, M., Rojas, J. I., and Gutierrez, D. M. Smooth muscle relaxing activity of gentiopicroside isolated from Gentiana spathacea. In foods and beverages, gentian is used as an ingredient. Effects of Gentiana lutea ssp. Scutellaria Baicalensis Root Extract. Skin. [Acute dietary poisoning by white hellebore (Veratrum album L.). The iridoids have been analyzed by thin-layer chromatography, micellar electrokinetic capillary chromatography, and high-performance liquid chromatography mass spectrometry.Bricout 1974, Glatz 2000, Szucs 2002, In addition to iridoids, the roots contain xanthones and triterpenes.Hayashi 1988, Kakuda 2003, Toriumi 2003 The reported pyridine alkaloids gentianine and gentialutine are thought to be artifacts of basic extraction derived from the iridoids. Gentian is used in combination with European elderflower, verbena, cowslip flower, and sorrel for treating symptoms of sinus infections (sinusitis). Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Suzuki, O., Katsumata, Y., and Oya, M. Inhibition of monoamine oxidase by isogentisin and its 3-O-glucoside. Surgery: Because gentian might affect blood pressure, there is a concern that it might interfere with blood pressure control during and after surgery. View abstract. Gentiana lutea root extract exerts anti-atherosclerotic effects in diabetic rats.. Gentiana lutea root extract prevents endothelial inflammation and smooth muscle cell migration.. Categories: Skin-Soothing, Antioxidants, Plant Extracts. In addition, the extracts were active in several wound-healing models.Chen 2008, Mathew 2004, Ozturk 2006, Radix Gentianae Lutea and gentian extracts have been shown to exert antibacterial, antifungal, and antiprotozoal effects in vitro.WHO 1999, Methanolic extracts of the flowers and leaves of G. lutea demonstrated a wide range of activity against gram-positive and gram-negative bacteria and yeasts. It is used in combination with other products for malaria. Borgia, M., Sepe, N., Borgia, R., and Ori-Bellometti, M. Pharmacological activity of a herb extract: a controlled clinical study. The root of the licorice plant is used in medicine and herbal supplements 1.The root is often called "sweet root" because it contains a chemical compound that is approximately 50 times sweeter than table sugar. Gentian is applied to the skin for treating wounds and cancer. ©1996-2020 RxList, Inc. All rights reserved. Gentiana lutea (Gentian) root extract. Pharmacol Biochem Behav 2005;81:535-42. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. Benefits include improving digestion, supporting the liver and gallbladder, treating fungal and bacterial infections, supporting the nervous system, reducing inflammation, and fighting pain. The root is used to make concentrated extract (bitters), teas, tonics, liqueurs, powders, capsules and ⦠Gentiana Lutea Root Extract. Gentian root consists of xanthones, triterpenoids and other constituents. The roots and rhizomes of G. lutea are used medicinally.Meyer 1934, PLANTS 2010, WHO 1999, G. acaulis is a smaller herb with a basal rosette of lance-shaped leaves and generally grows to 10 cm in height. View abstract. Studies on the evaluation of crude drugs. Exp Toxicol Pathol. The herb is used as a liver tonic and to stimulate an insufficient production of gastric juices, bile, and saliva. Active principle of Gentiana, isovitexin, blocks TNF-α induced expression of adhesion molecules in endothelial cells.. Isovitexin attenuates PDGF-BB induced ROS/PLC-γ/[Ca 2+] i signaling in smooth muscle cells. Classical texts include hypertension as a contraindication, but the reasons are difficult to substantiate.WHO 1999, Mutagenicity has been demonstrated for methanolic extracts in Salmonella assays.WHO 1999, The highly toxic white hellebore (Veratrum album L.) often grows in close proximity to gentian. Gentian contains a chemical that might dilate blood vessels. Other names include 'yellow gentian', 'bitter root', 'bitterwort', 'centiyane', 'genciana', and ⦠Overall, gentian purifies and is said to strengthen the entire human system. A propos of 5 cases]. Select one or more newsletters to continue. Licorice is a plant used to flavor foods and beverages. However, because gentian is most often consumed in alcoholic beverages, it is difficult to distinguish the effects of gentian from those of alcohol. Radix Gentianae Lutea is contraindicated in GI or duodenal ulcer. Gentiana lutea is traditionally used for indigestion, liver dysfunction, and fatigue.Among the many active compounds are gentiopicroside and amarogentine. et Song. Sticher, O. and Meier, B. Quantitative determination of the bitter principles in the roots of Gentiana lutea and Gentiana purpurea with HPLC [high-pressure liquid chromatography]. Toriumi Y, Kakuda R, Kikuchi M, et al. View abstract. The extract is usually taken in very small doses that do not appear to cause adverse effects; however, it may cause GI irritation, resulting in nausea and vomiting and, rarely, headache. The root of the plant and, less commonly, the bark are used to make medicine. It is used to alleviate inflammations in the gallbladder. I. Aesculus hippocastaneum L., Arctostaphylos uva-ursi Spreng., Fraxinus excelsior L., Gentiana lutea L., Glyccyrhiza glabra L., Hamamelis virginiana L., Hypericum perforatum L., Olea europea L., Salix alba L., and Silybum marianum Gaertn. Promotes the production of saliva, gastric juices and bile which aid in digestion. Slow drying permits enzymatic hydrolysis of gentiopicrin into gentiogenin and glucose, therefore reducing bitterness. Ozturk, N., Baser, K. H., Aydin, S., Ozturk, Y., and Calis, I. With the necessary nutrients and elimination of ⦠Enhancing cellular regeneration while preventing collagen breakdown are the keys to restore youthful appearance of the skin. The root and rhizome portions are longitudinally wrinkled. Title 21. Phytochemistry 2004;65:2255-60. Gentian is an herb. Electronic Code of Federal Regulations. There are no clinical studies to substantiate this dosage recommendation.WHO 1999, Mutagenic activity has been demonstrated in assays, and G. lutea has been traditionally used as an emmenagogue. Gentian is applied to the skin for treating wounds and cancer. Chericoni S, Testai L, Calderone V, et al. (Tokyo) 2003;51(7):885-887. The flowers and leaves of G. lutea contain iridoids, flavonoids, and xanthones.Menkovic 2000, Quality clinical trials evaluating the effect of gentian or its chemical constituents are lacking.WHO 1999, Gentianine and gentiopicroside have been shown to exert a measurable anti-inflammatory and analgesic effect in animals. Health Benefits of Gentian Root Most of the benefits of gentian root revolve around this herbâs ability to stimulate and tone the entire digestive system. RxList does not provide medical advice, diagnosis or treatment. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. Tomic M, Tovilovic G, Butorovic B, et al. Planta Med 2003;69:770-2. Hayashi, T. and Yamagishi, T. Two xanthone glycosides from Gentiana lutea. Gentian is used to treat fungal infections and different kinds of wounds. Amin, A. Ketoconazole-induced testicular damage in rats reduced by Gentiana extract. Taking gentian along with medications for high blood pressure might cause your blood pressure to go too low. Gentian is used for digestion problems such as loss of appetite, fullness, intestinal gas, diarrhea, gastritis, heartburn, and vomiting. Bricout, J. Ann.Med.Interne (Paris) 1985;136(2):125-128. View abstract. Native to the mountains of central and southern Europe, G. lutea is a perennial herb that grows to 1.8 m with erect stems and smooth, oval leaves. Healthier Skin Gentian herbs are rich with vitamins, minerals and antioxidants that make the body healthy. Gentian Root Extract is used in bath and skin care. Gentian (Gentiana lutea) root is an excellent bitter, that stimulates the appetite and digestion. Phytochemistry 1988;27:3696-3699. Part of the gentian plant, constituents of which have skin-soothing and antioxidant benefits. Gentiana lutea applied to the skin for the treatment of various wounds and fungal infections. We comply with the HONcode standard for trustworthy health information -. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. Hydrolyzed Rice Bran Extract. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. Last updated on Sep 21, 2020. See additional information. Garnier, R., Carlier, P., Hoffelt, J., and Savidan, A. Planta Medica 1980;38:344-350. Schmieder, A., Schwaiger, S., Csordas, A., Backovic, A., Messner, B., Wick, G., Stuppner, H., and Bernhard, D. Isogentisin--a novel compound for the prevention of smoking-caused endothelial injury. View abstract. Gentian extract is used as a bitter in concentrations of approximately 0.02% in nonalcoholic beverages. Of foods, cosmetics, and fatigue.Among the many active compounds are gentiopicroside amarogentine!, et al ingested before meals are reputed to improve the blood flow damaged! 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