Was completely out of control, too fucked to be in public. So you really need to understand the role of Glutamate, NMDA, and AMPA for your circumstances. It just slightly improves motivation and short term memory. I used to be prescribed dex, I have taken it 100's of times and mixed it alcohol, psychedelics, caffeine, you name it. Piracetam potentiates amphetamines. Reddit user fatetrader: Piracetam works for me really well, it truly sets my tongue free. The first two would be too strong and would be advised not to combine with your case unless you're really sure you know what is actually going on. Thanks for listening, hope this helps someone. I personally can see its magic mostly when in social situations where I have to talk. It is an inexpensive option and one that is good for beginning neurohackers. It is my hope that cannabis may prove to limit the impact of any possible glutamate excitotoxicity while simultaneously boosting attention and euphoria (for good measure). I haven't seen any study on the interactions of the two except a mouse study on amphetamine + piracetam which notes internet reports, but this is hardly enough research: http://www.ncbi.nlm.nih.gov/pubmed/22607774. The low affinity, uncompetitive nature, and rapid off-rate kinetics of memantine at the level of the NMDA receptor-channel, however, preserves the function of the receptor at synapses, as it can still be activated by physiological release of glutamate following depolarization of the presynaptic neuron. Saw in another thread: Take 30mg-60mg dextromethorphan daily for about a week and your adhd med tolerance will be greatly diminished. Next time take vitamin c to counter the amphetamine with your magnesium. Like Methylphenidate, Adderall works by increasing noradrenaline and dopamine levels in the brain, prompting a significant increase in brain function. I think I still will, but I'll keep my doses low. Did you dose multiple times through out the day? Incredibly overstimulated. This causes decreased GABA release and disinhibits AMPA and mGlu. Positive effects touted by those who have used this nootropic as posted on Longecity and Reddit include: Enhanced libido; Cleared brain fog; Improved mood; Boosted wakefulness; Vision enhancement; Cured erectile dysfunction; The side effects that users report are as follows: Depression; Brain fog; Fatigue; Headache; Digestive problems Not all the time, though. I did a quick search and didn't see anything. So you want Glutamate but you want to keep it under control. I think the consensus is still not clear on the racetams and their affect on tolerance. Thanks for the responses everyone! With regards to choosing the best Adderall alternative, you must understand that there is no one-size-fits-all choice that can go well for everyone. For most of the psychedelic purchases you make online, you'll need some form of cryptocurrency such Bitcoin and, in most cases, if you want to remain anonymous, a cloaked or “tor” browser. I usually take about 800mg piracetam with about 10mg of adderall. It was great. It’s only available by prescription. I really want to try some Aniracetam because my social skills are awful. Piracetam generally takes about two weeks of daily dosing to achieve full impact on the user’s brain. Once again science forgoes a potential benefit to society by remaining caught up with recreational users of substances. Anecdotally, I've combined Piracetam, Oxiracetam, Nicotine, and Amphetamine (doses of 2g, 1600mg, ??? As an alternative to Adderall, there is no strong dump of neurochemicals (dopamine), but instead a steady clarity. Memantine is a low-affinity voltage-dependent uncompetitive antagonist at glutamatergic NMDA receptors. It makes me really want to talk and I even like to start topics. I got them the first time trying each stronger racetam tho. They both share a pyrrolidone nucleus at their core, but aniracetam adds an anisoyl ring (hence the name). Feel free to poke holes and critique because I am by no means an expert and am not claiming to be just merely conveying and gathering information. I've tried to cut them out and only use nootropics, but if i dont take my adderall i just want to sit in bed all day. 7. So you still want to preserve the function of what is going on but have a control system that checks it from causing damage and building tolerance. 1.1 … What People Have to Say About Piracetam. Experienced none of these effects. Adderall is a commonly prescribed stimulant and is part of the amphetamine class of drugs. There is no doubt about that. However, you can mitigate those risks with supplementation. I copy and pasted a lot of wiki stuff and grabbed a lot of info from /u/MisterYouAreSoDumb. Glutamatergic drugs are generally hallucinogenic. It’s important to understand the risks of amphetamines such as Adderall, especially in light of their Schedule II government status. All this being said /u/MisterYouAreSoDumb has done much more research into this and provides a ton of insight on the subject. Piracetam is the original racetam, first synthesized by the “Father Of Nootropics” Dr. Corneliu E. Giurgea in the 1960s. I've often why Doctors don't prescribe an NMDA antagonist if they really did reduce tolerance... Anyhoo, Piracetam releases Dopamine and bunch of other things. Yeah piracetam scares me more than amphetamine. Press J to jump to the feed. So interesting! 3 Dimond SJ, Brouwers EM. That's absurd, and these results are really only relevant to massive overdoses of both compounds. ... No, unlike stimulants such as Adderall, noopept will not get you high. Amphetamine can be neurotoxic. To top it all up, Phenylpiracetam is classified as an anxiolytic and anti-depressant all thanks to studies done in mice demonstrating that it can prevent anxiety and increase locomotion . Piracetam was the original racetam nootropic, and phenylpiracetam is a newer version that acts quicker and has higher bioavailability. ... Noopept Reddit Reviews. I wonder if the difference is a predisposition to anxiety vs a naturally calm personality, making the stack manageable for some but overkill for others. My tongue is lets just say much more flexible I can spell out quicker without it getting entangled in difficult words and flow of ideas into mouth is so much more synchronized and … There seems to be a lack of empirical information on of amp/mph and racetam combinations. It probably has MAOI effects as well. Though others have claimed a similar relationship it's far from a consensus. Piracetam adds more focus and mental clarity to the mix. This is just a panic attack. This would be a very time-consuming experiment. Its name is derived from its ability to be activated by the artificial glutamate analog AMPA. .c_dVyWK3BXRxSN3ULLJ_t{border-radius:4px 4px 0 0;height:34px;left:0;position:absolute;right:0;top:0}._1OQL3FCA9BfgI57ghHHgV3{-ms-flex-align:center;align-items:center;display:-ms-flexbox;display:flex;-ms-flex-pack:start;justify-content:flex-start;margin-top:32px}._1OQL3FCA9BfgI57ghHHgV3 ._33jgwegeMTJ-FJaaHMeOjV{border-radius:9001px;height:32px;width:32px}._1OQL3FCA9BfgI57ghHHgV3 ._1wQQNkVR4qNpQCzA19X4B6{height:16px;margin-left:8px;width:200px}._39IvqNe6cqNVXcMFxFWFxx{display:-ms-flexbox;display:flex;margin:12px 0}._39IvqNe6cqNVXcMFxFWFxx ._29TSdL_ZMpyzfQ_bfdcBSc{-ms-flex:1;flex:1}._39IvqNe6cqNVXcMFxFWFxx .JEV9fXVlt_7DgH-zLepBH{height:18px;width:50px}._39IvqNe6cqNVXcMFxFWFxx ._3YCOmnWpGeRBW_Psd5WMPR{height:12px;margin-top:4px;width:60px}._2iO5zt81CSiYhWRF9WylyN{height:18px;margin-bottom:4px}._2iO5zt81CSiYhWRF9WylyN._2E9u5XvlGwlpnzki78vasG{width:230px}._2iO5zt81CSiYhWRF9WylyN.fDElwzn43eJToKzSCkejE{width:100%}._2iO5zt81CSiYhWRF9WylyN._2kNB7LAYYqYdyS85f8pqfi{width:250px}._2iO5zt81CSiYhWRF9WylyN._1XmngqAPKZO_1lDBwcQrR7{width:120px}._3XbVvl-zJDbcDeEdSgxV4_{border-radius:4px;height:32px;margin-top:16px;width:100%}._2hgXdc8jVQaXYAXvnqEyED{animation:_3XkHjK4wMgxtjzC1TvoXrb 1.5s ease infinite;background:linear-gradient(90deg,var(--newCommunityTheme-field),var(--newCommunityTheme-inactive),var(--newCommunityTheme-field));background-size:200%}._1KWSZXqSM_BLhBzkPyJFGR{background-color:var(--newCommunityTheme-widgetColors-sidebarWidgetBackgroundColor);border-radius:4px;padding:12px;position:relative;width:auto} 100mg of oxiracetam, for example, is a near micro-dosage on its own yet seems to potentiate amphetamines in a fairly marked and beneficial manner. /*# sourceMappingURL=https://www.redditstatic.com/desktop2x/chunkCSS/TopicLinksContainer.361933014be843c79476.css.map*/._2ppRhKEnnVueVHY_G-Ursy{-ms-flex-align:center;align-items:center;display:-ms-flexbox;display:flex;margin:22px 0 0;min-height:200px;overflow:hidden;position:relative}._2KLA5wMaJBHg0K2z1q0ci_{margin:0 -7px -8px}._1zdLtEEpuWI_Pnujn1lMF2{bottom:0;position:absolute;right:52px}._3s18OZ_KPHs2Ei416c7Q1l{margin:0 0 22px;position:relative}.LJjFa8EhquYX8xsTnb9n-{filter:grayscale(40%);position:absolute;top:11px}._2Zjw1QfT_iMHH7rfaGsfBs{-ms-flex-align:center;align-items:center;background:linear-gradient(180deg,rgba(0,121,211,.24),rgba(0,121,211,.12));border-radius:50%;display:-ms-flexbox;display:flex;height:25px;-ms-flex-pack:center;justify-content:center;margin:0 auto;width:25px}._2gaJVJ6_j7vwKV945EABN9{background-color:var(--newCommunityTheme-button);border-radius:50%;height:15px;width:15px;z-index:1} --> Cue 6-8 months of somewhat regular use/using other racetams as well (ani, phenyl). - posted in Brain Health: Im prescribed 10mg Adderall IR twice a day. ._1PeZajQI0Wm8P3B45yshR{fill:var(--newCommunityTheme-actionIcon)}._1PeZajQI0Wm8P3B45yshR._3axV0unm-cpsxoKWYwKh2x{fill:#ea0027} Modafinil and Piracetam go great with each other. Piracetam. But that’s not all, a closer look at its formulation reveals that it can also function as an energy booster just the same way Adderall does. 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I placed a moratorium on continued experimentation until I'd taken the time to better understand how piracetam, oxiracetam, and amphetamine could interact at glutamate receptors. But this is an excellent starting point. As for racetam tolerance itself, people used to argue about this all the time at longecity. Whenever I do it's just got that subtle bit. I take Alpha-GPC twice a day. I even had phases where I got all these effects where the initial effect was impulsive and chill and hungry but then 3 hours later extreme panic attacks and super bright vision and trails. ._2YJDRz5rCYQfu8YdgB_neb{overflow:hidden;position:relative}._2YJDRz5rCYQfu8YdgB_neb:before{background-image:url(https://www.redditstatic.com/desktop2x/img/reddit_pattern.png);content:"";filter:var(--newCommunityTheme-invertFilter);height:100%;position:absolute;width:100%}._37WD6iicVS6vGN0RomNTwh{padding:0 12px 12px;position:relative} I would also make sure that my diet contained the appropriate levels of tyrosine and creatine, or I would supplement those too. More like always being paranoid about anything I'm feeling, from stimulant tachycardia to trails in my vision all the time. Anyhow, I merely brought the whole thing up just to urge anyone considering the combo to go slowly with lower doses at first. ._2cHgYGbfV9EZMSThqLt2tx{margin-bottom:16px;border-radius:4px}._3Q7WCNdCi77r0_CKPoDSFY{width:75%;height:24px}._2wgLWvNKnhoJX3DUVT_3F-,._3Q7WCNdCi77r0_CKPoDSFY{background:var(--newCommunityTheme-field);background-size:200%;margin-bottom:16px;border-radius:4px}._2wgLWvNKnhoJX3DUVT_3F-{width:100%;height:46px} I would like someone to clear it up though. ._3Qx5bBCG_O8wVZee9J-KyJ{border-top:1px solid var(--newRedditTheme-line);margin-top:16px;padding-top:16px}._3Qx5bBCG_O8wVZee9J-KyJ ._2NbKFI9n3wPM76pgfAPEsN{margin:0;padding:0}._3Qx5bBCG_O8wVZee9J-KyJ ._2NbKFI9n3wPM76pgfAPEsN ._2btz68cXFBI3RWcfSNwbmJ{font-family:Noto Sans,Arial,sans-serif;font-size:14px;font-weight:400;line-height:21px;display:-ms-flexbox;display:flex;-ms-flex-pack:justify;justify-content:space-between;margin:8px 0}._3Qx5bBCG_O8wVZee9J-KyJ ._2NbKFI9n3wPM76pgfAPEsN ._2btz68cXFBI3RWcfSNwbmJ.QgBK4ECuqpeR2umRjYcP2{opacity:.4}._3Qx5bBCG_O8wVZee9J-KyJ ._2NbKFI9n3wPM76pgfAPEsN ._2btz68cXFBI3RWcfSNwbmJ label{font-size:12px;font-weight:500;line-height:16px;display:-ms-flexbox;display:flex;-ms-flex-align:center;align-items:center}._3Qx5bBCG_O8wVZee9J-KyJ ._2NbKFI9n3wPM76pgfAPEsN ._2btz68cXFBI3RWcfSNwbmJ label svg{fill:currentColor;height:20px;margin-right:4px;width:20px}._3Qx5bBCG_O8wVZee9J-KyJ ._4OtOUaGIjjp2cNJMUxme_{-ms-flex-align:center;align-items:center;display:-ms-flexbox;display:flex;-ms-flex-pack:justify;justify-content:space-between;padding:0;width:100%}._3Qx5bBCG_O8wVZee9J-KyJ ._4OtOUaGIjjp2cNJMUxme_ svg{display:inline-block;height:12px;width:12px}.isInButtons2020 ._4OtOUaGIjjp2cNJMUxme_{padding:0 12px}.isInButtons2020 ._1ra1vBLrjtHjhYDZ_gOy8F{font-family:Noto Sans,Arial,sans-serif;font-size:12px;font-weight:700;letter-spacing:unset;line-height:16px;text-transform:unset}._1ra1vBLrjtHjhYDZ_gOy8F{--textColor:var(--newCommunityTheme-widgetColors-sidebarWidgetTextColor);--textColorHover:var(--newCommunityTheme-widgetColors-sidebarWidgetTextColorShaded80);font-size:10px;font-weight:700;letter-spacing:.5px;line-height:12px;text-transform:uppercase;color:var(--textColor);fill:var(--textColor);opacity:1}._1ra1vBLrjtHjhYDZ_gOy8F._2UlgIO1LIFVpT30ItAtPfb{--textColor:var(--newRedditTheme-widgetColors-sidebarWidgetTextColor);--textColorHover:var(--newRedditTheme-widgetColors-sidebarWidgetTextColorShaded80)}._1ra1vBLrjtHjhYDZ_gOy8F:active,._1ra1vBLrjtHjhYDZ_gOy8F:hover{color:var(--textColorHover);fill:var(--textColorHover)}._1ra1vBLrjtHjhYDZ_gOy8F:disabled,._1ra1vBLrjtHjhYDZ_gOy8F[data-disabled],._1ra1vBLrjtHjhYDZ_gOy8F[disabled]{opacity:.5;cursor:not-allowed} Counter-anecdote, I've been taking 1600mg of piracetam, 30mg of noopept and 40mg of adderall daily for a while. Experience 2: ~800mg piracetam this day. Pretty sure you wouldn't be able to write a FAQ purely based on anecdotes. However, you may feel a mild lift after using it. Effects were basically the same as the first time. To find a nootropic stack that mimics the Adderall effect, you’ll have to sacrifice just about 20% of the strength. I thought I was well-experienced with piracetam. ._3gbb_EMFXxTYrxDZ2kusIp{margin-bottom:24px;text-transform:uppercase;width:100%}._3gbb_EMFXxTYrxDZ2kusIp:last-child{margin-bottom:10px} Reddit II. So they are definitely nootropic. In 2015, nootropics sales … ._9ZuQyDXhFth1qKJF4KNm8{padding:12px 12px 40px}._2iNJX36LR2tMHx_unzEkVM,._1JmnMJclrTwTPpAip5U_Hm{font-size:16px;font-weight:500;line-height:20px;color:var(--newCommunityTheme-bodyText);margin-bottom:40px;padding-top:4px}._306gA2lxjCHX44ssikUp3O{margin-bottom:32px}._1Omf6afKRpv3RKNCWjIyJ4{font-size:18px;font-weight:500;line-height:22px;border-bottom:2px solid var(--newCommunityTheme-line);color:var(--newCommunityTheme-bodyText);margin-bottom:8px;padding-bottom:8px}._2Ss7VGMX-UPKt9NhFRtgTz{margin-bottom:24px}._3vWu4F9B4X4Yc-Gm86-FMP{border-bottom:1px solid var(--newCommunityTheme-line);margin-bottom:8px;padding-bottom:2px}._3vWu4F9B4X4Yc-Gm86-FMP:last-of-type{border-bottom-width:0}._2qAEe8HGjtHsuKsHqNCa9u{font-size:14px;font-weight:500;line-height:18px;color:var(--newCommunityTheme-bodyText);padding-bottom:8px;padding-top:8px}.c5RWd-O3CYE-XSLdTyjtI{padding:8px 0}._3whORKuQps-WQpSceAyHuF{font-size:12px;font-weight:400;line-height:16px;color:var(--newCommunityTheme-actionIcon);margin-bottom:8px}._1Qk-ka6_CJz1fU3OUfeznu{margin-bottom:8px}._3ds8Wk2l32hr3hLddQshhG{font-weight:500}._1h0r6vtgOzgWtu-GNBO6Yb,._3ds8Wk2l32hr3hLddQshhG{font-size:12px;line-height:16px;color:var(--newCommunityTheme-actionIcon)}._1h0r6vtgOzgWtu-GNBO6Yb{font-weight:400}.horIoLCod23xkzt7MmTpC{font-size:12px;font-weight:400;line-height:16px;color:#ea0027}._33Iw1wpNZ-uhC05tWsB9xi{margin-top:24px}._2M7LQbQxH40ingJ9h9RslL{font-size:12px;font-weight:400;line-height:16px;color:var(--newCommunityTheme-actionIcon);margin-bottom:8px} I can't stress enough how scary this was. You can split your Modafinil dose (200mg to 100mg or 100mg to 50mg, depending on tolerance) in half and supplement the other half with 0.8g of Piracetam. By binding to the NMDA receptor with a higher affinity than Mg2+ ions, memantine is able to inhibit the prolonged influx of Ca2+ ions, particularly from extrasynaptic receptors, which forms the basis of neuronal excitotoxicity. I take Adderal and Piracetam all the time, and for years - no real interaction effects. Awesome this is very helpful. I appreciate it!! It did this for a week straight. Had plenty of panic attacks in my life and these were not. Replacing Adderall with Piracetam. The beauty of Oxiracetam is that unlike other Racetams such as Aniracetam and its older brother Piracetam is that it … It's worth considering what else you consumed aside from the obvious candidates. Okay, so this is an anecdotal report, but I ask that you believe me when I say I am well experienced with dexedrine and piracetam. It may work for some, but considering I had a very bad reaction on 10mg and 5mg, I don't know how you could cautiously test this combination. In moderation. I would also look at the Adderal since it can be very strong. It’s made out of four salts of the two enantiomers of amphetamine. I normally do 800mg 3x a day, but lately I've been only using 800-1600mg of piracetam per day. I take Alpha-GPC twice a day. Aniracetam vs. Piracetam. You’ll walk so tall and with confidence you’ll feel like you’re 6’5” … They don't really seem to multiply the effects, just make thoughts flow smoother. And, if anyone can answer, do you think I was in real danger or was it all psychological? I don't want anyone else to go through what I did. Has anyone ever put together a decent guide on this sub or elsewhere to help balance those kind of effects? I don't know if I was in any real physical danger from this combo but I do know I was under extreme psychological distress. Discussion of nootropics and cognitive enhancers. Yeah nothing else really comes close, although I've felt some effects from oxiracetam too (but it's a very distant second). I get very strong panic attacks when mixing Dexedrine with other stimulants, even the other stimulants by themselves don't cause it for me. Confidence like you wouldn’t believe. But since im prescribed … Noopept, for me, had a strong effect for the first four days and then kind of toned down. .FIYolDqalszTnjjNfThfT{max-width:256px;white-space:normal;text-align:center} I would say don't and do a lot more research. Doing work in the morning has never been as fast and high quality. ... Like Adderall, aniracetam has mood-enhancing effects, but they are created in a sustainable … .LalRrQILNjt65y-p-QlWH{fill:var(--newRedditTheme-actionIcon);height:18px;width:18px}.LalRrQILNjt65y-p-QlWH rect{stroke:var(--newRedditTheme-metaText)}._3J2-xIxxxP9ISzeLWCOUVc{height:18px}.FyLpt0kIWG1bTDWZ8HIL1{margin-top:4px}._2ntJEAiwKXBGvxrJiqxx_2,._1SqBC7PQ5dMOdF0MhPIkA8{height:24px;vertical-align:middle;width:24px}._1SqBC7PQ5dMOdF0MhPIkA8{-ms-flex-align:center;align-items:center;display:-ms-inline-flexbox;display:inline-flex;-ms-flex-direction:row;flex-direction:row;-ms-flex-pack:center;justify-content:center} Then it became more consistent, but no panic/mania or anxiety when combined with stimulants. Hey all- I felt a responsibility to post on this combination, which I have had 2 experiences with in the past 7 days. Users that combine the two report more efficient effects than taken separately. It's given me panic attacks. Also, just start out with piracetam for the time being and see how it effects you before you shell out money for the aniracetam. The idea behind the rapid tolerance buildup of amphetamine is the influx of Ca2+ caused by our most abundant excitatory neurotransmitter, Glutamate. NMDA receptor antagonist disrupts acute and chronic effects of methylphenidate. Recommended Dosage (split into two doses): 2,000 mg/day Piracetam; 600 mg/day Adrafinil; Piracetam and Adderall. I have used other nootropics before, but noopept is so potent and strong that I can improve my … Discussion of nootropics and cognitive enhancers. I do 5-6g of Piracetam followed by Amphetamine without any issues. The racetam-class of nootropics have a pyrrolidone nucleus at their core. But I can confirm racetams definitely seem to potentiate amphetamine. Still, I don't think the other substances were the culprit. if the euphoria was sustainable. Sorry, I disagree. Adderall and Racetams? .ehsOqYO6dxn_Pf9Dzwu37{margin-top:0;overflow:visible}._2pFdCpgBihIaYh9DSMWBIu{height:24px}._2pFdCpgBihIaYh9DSMWBIu.uMPgOFYlCc5uvpa2Lbteu{border-radius:2px}._2pFdCpgBihIaYh9DSMWBIu.uMPgOFYlCc5uvpa2Lbteu:focus,._2pFdCpgBihIaYh9DSMWBIu.uMPgOFYlCc5uvpa2Lbteu:hover{background-color:var(--newRedditTheme-navIconFaded10);outline:none}._38GxRFSqSC-Z2VLi5Xzkjy{color:var(--newCommunityTheme-actionIcon)}._2DO72U0b_6CUw3msKGrnnT{border-top:none;color:var(--newCommunityTheme-metaText);cursor:pointer;padding:8px 16px 8px 8px;text-transform:none}._2DO72U0b_6CUw3msKGrnnT:hover{background-color:#0079d3;border:none;color:var(--newCommunityTheme-body);fill:var(--newCommunityTheme-body)} As a water-soluble racetam, it is not as bioavailable as the others, leading to a need to take more of it to feel an effect. Weeks when I 've never seen an incident where they even directly affect each other effectiveness! 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